Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | GRK2 | P25098 | 6/20 | 0.48 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 4/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778428 | 1.00 | ROCK1 (0.48) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29778526 | 0.94 | ROCK1 (0.46) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29135995 | 0.90 | GRK2 (0.46) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29778508 | 0.90 | GRK2 (0.46) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29778571 | 0.90 | GRK2 (0.41) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29135985 | 0.90 | GRK2 (0.41) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL30656530 | 0.89 | SLC2A1 (0.45) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29135970 | 0.89 | SLC2A1 (0.45) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29779089 | 0.88 | ROCK1 (0.50) | ROCK1ROCK2GRK2GRK1SLC2A1 | |
| SCHEMBL29135990 | 0.88 | ROCK1 (0.50) | ROCK1ROCK2GRK2GRK1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |