Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24738013 | 1.00 | XPO1 (0.42) | XPO1MAPTALDH1A1MAOBNPC1 | |
| SCHEMBL1219446 | 0.88 | MAPT (0.54) | MAPTALDH1A1MAOBNPC1POLB | |
| SCHEMBL18511984 | 0.85 | KDM4E (0.40) | MAPTALDH1A1MAOBNPC1POLB | |
| SCHEMBL14860918 | 0.84 | XPO1 (0.40) | XPO1MAPTALDH1A1MAOBNPC1 | |
| SCHEMBL14860920 | 0.84 | XPO1 (0.40) | XPO1MAPTALDH1A1MAOBNPC1 | |
| SCHEMBL30194560 | 0.84 | XPO1 (0.40) | XPO1MAPTALDH1A1MAOBNPC1 | |
| SCHEMBL18133776 | 0.83 | CYP2C9 (0.38) | XPO1MAPTALDH1A1MAOBNPC1 | |
| SCHEMBL29053531 | 0.82 | CYP3A4 (0.40) | XPO1MAPTALDH1A1NPC1POLB | |
| SCHEMBL30194087 | 0.82 | CYP3A4 (0.40) | XPO1MAPTALDH1A1NPC1POLB | |
| SCHEMBL13303891 | 0.82 | DPP4 (0.42) | XPO1MAPTALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |