Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365396 | 0.89 | PDGFRB (0.76) | PDGFRAPDGFRBKDRFGFR2EGFR | |
| SCHEMBL168048 | 0.88 | PDGFRB (0.79) | PDGFRAPDGFRBKDRFGFR2EGFR | |
| SCHEMBL167759 | 0.86 | PDGFRB (0.71) | PDGFRAPDGFRBKDRFGFR2EGFR | |
| SCHEMBL4470477 | 0.85 | PDGFRA (0.74) | PDGFRAPDGFRBKDRFGFR2 | |
| SCHEMBL1875038 | 0.85 | PDGFRA (0.69) | PDGFRAPDGFRBKDRFGFR2EGFR | |
| SCHEMBL30467929 | 0.85 | PDGFRA (0.69) | PDGFRAPDGFRBKDRFGFR2EGFR | |
| SCHEMBL4482576 | 0.85 | PDGFRA (0.69) | PDGFRAPDGFRBKDRFGFR2EGFR | |
| SCHEMBL3898473 | 0.84 | PDGFRA (0.64) | PDGFRAPDGFRBKDRFGFR2EGFR | |
| SCHEMBL5208153 | 0.83 | PDGFRA (0.56) | PDGFRAPDGFRBKDRFGFR2MET | |
| SCHEMBL14967467 | 0.82 | PDGFRB (0.66) | PDGFRAPDGFRBKDRFGFR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117327061-A | Preparation method of tivalzanib hydrochloride and related substances | 武汉迈德森医药科技股份有限公司 | 2024-01-02 | — | — | CN | disclosed |