SCHEMBL29137942

SCHEMBL29137942

Fc1ccc(OC2CCC2)cc1C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.45
EPHX2 P34913 2/20 0.43
PTGS1 P23219 1/20 0.43
PTGS2 P35354 1/20 0.43
AR P10275 5/20 0.42
HRH3 Q9Y5N1 5/20 0.41
FFAR4 Q5NUL3 1/20 0.40
ACACB O00763 1/20 0.39
PARP10 Q53GL7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1229572 0.86 HRH1 (0.47) EPHX2HRH3
Hydrochloric Acid SCHEMBL71850 0.84 HRH1 (0.46) EPHX2HRH3
SCHEMBL19294270 0.82 PTGS1 (0.48) PDK2EPHX2PTGS1PTGS2FFAR4
SCHEMBL29890071 0.81 KDM1A (0.40) ARACACB
SCHEMBL26933273 0.81 KDM1A (0.40) ARACACB
SCHEMBL15477158 0.81 KDM1A (0.40) ARACACB
SCHEMBL15477156 0.81 KDM1A (0.40) ARACACB
SCHEMBL17012836 0.80 PTGS1 (0.51) PDK2PTGS1PTGS2FFAR4PARP10
Hydrochloric Acid SCHEMBL9277795 0.80 KDM1A (0.39) ARACACB
Hydrochloric Acid SCHEMBL30636296 0.80 KDM1A (0.39) ARACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117062804-A 1, 3-substituted cyclobutyl derivatives and their use 诺华股份有限公司 2023-11-14 CN disclosed