Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29141 | 0.85 | NTRK1 (0.32) | METMAPK14MAP4K4OPRK1 | |
| SCHEMBL29252 | 0.84 | MEN1 (0.32) | — | |
| SCHEMBL6890894 | 0.84 | JAK1 (0.36) | METTTKCYP3A4 | |
| SCHEMBL599904 | 0.83 | KDM4E (0.31) | CYP3A4 | |
| SCHEMBL15339605 | 0.81 | MEN1 (0.35) | MAPK14TTKOPRK1 | |
| SCHEMBL19017893 | 0.80 | RET (0.36) | MET | |
| SCHEMBL30348 | 0.80 | MEN1 (0.32) | — | |
| SCHEMBL2679978 | 0.79 | GRK2 (0.31) | — | |
| SCHEMBL1289939 | 0.78 | PIM1 (0.33) | — | |
| SCHEMBL28283 | 0.78 | KDM4E (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |