Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.36 |
| ▸ | TNKS | O95271 | 4/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | GUSB | P08236 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 3/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.33 |
| ▸ | TUBB | P07437 | 2/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423892 | 0.84 | HTT (0.41) | PARP1GUSBKDM4EPTGESPIM1 | |
| SCHEMBL22101466 | 0.83 | PARP1 (0.37) | PARP1TNKSTNKS2PARP2PARP3 | |
| SCHEMBL30784338 | 0.81 | NPC1 (0.39) | PARP1TNKSTNKS2PARP2GUSB | |
| SCHEMBL577862 | 0.77 | PARP1 (0.51) | PARP1TNKSTNKS2PARP2GUSB | |
| SCHEMBL18128478 | 0.74 | IP6K1 (0.56) | PARP1TNKS2PIM1PIM2 | |
| SCHEMBL30826848 | 0.73 | PARP1 (0.36) | PARP1DAOPIM1PIM2 | |
| SCHEMBL22028973 | 0.73 | PARP1 (0.36) | PARP1DAOPIM1PIM2 | |
| SCHEMBL29142205 | 0.72 | GRIN2D (0.33) | PARP1TNKSTNKS2KDM4E | |
| SCHEMBL29937099 | 0.69 | MAP2 (0.42) | PARP1DAOKDM4EMAP2 | |
| SCHEMBL27142990 | 0.69 | MAP2 (0.42) | PARP1DAOKDM4EMAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320132-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117083279-A | Oxazepine compounds and their use in the treatment of cancer | 基因泰克公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2022216762-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2022-10-13 | — | — | WO | disclosed |