Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912839 | 0.99 | HRH3 (0.49) | HRH3HTTMEN1KMT2AUSP2 | |
| SCHEMBL1423482 | 0.93 | HRH3 (0.47) | HRH3HTTMEN1KMT2AUSP2 | |
| SCHEMBL1423087 | 0.92 | HRH3 (0.49) | HRH3HTTMEN1KMT2AUSP2 | |
| SCHEMBL2907126 | 0.88 | HRH3 (0.53) | HRH3HTTMEN1KMT2AUSP2 | |
| SCHEMBL2907958 | 0.87 | HRH3 (0.55) | HRH3POLBKCNH2ALDH1A1KDM4E | |
| SCHEMBL2913116 | 0.85 | HRH3 (0.53) | HRH3HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2909750 | 0.84 | HRH3 (0.52) | HRH3HTTALDH1A1TSHRL3MBTL1 | |
| SCHEMBL2906731 | 0.84 | HRH3 (0.66) | HRH3MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2913129 | 0.84 | HRH3 (0.51) | HRH3KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL2910178 | 0.84 | HRH3 (0.51) | HRH3MEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102215-B1 | 4,5,6,7-TETRAHYDRO-THIENO [2,3-C]PYRIDINES AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-09-01 | — | — | EP | claimed |