Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | KCNN3 | Q9UGI6 | 3/20 | 0.35 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.35 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 4/20 | 0.34 |
| ▸ | CDK7 | P50613 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CCNH | P51946 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573496 | 0.97 | PDE10A (0.57) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL5466448 | 0.95 | PDE10A (0.56) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL1022442 | 0.86 | PDE10A (0.53) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL14413740 | 0.84 | CHEK1 (0.73) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL7880188 | 0.82 | PDE10A (0.46) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL13117265 | 0.82 | PDE10A (0.51) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL14043377 | 0.82 | PDE10A (0.51) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL16086901 | 0.82 | PDE10A (0.48) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL584212 | 0.82 | PDE10A (0.48) | PDE10ACDK2CCNA2CCNA1CHEK1 | |
| SCHEMBL29152851 | 0.81 | CDK2 (0.50) | PDE10ACDK2CCNA2CCNA1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117486885-A | Use of pyrazolopyrimidines | 中国科学院上海药物研究所 | 2024-02-02 | — | — | CN | disclosed |