Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.32 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913931 | 0.91 | CRBN (0.69) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| Alcohol SCHEMBL2909873 | 0.90 | CRBN (0.64) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| Water SCHEMBL2915433 | 0.90 | CRBN (0.68) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| Methyl Alcohol SCHEMBL2913736 | 0.89 | CRBN (0.67) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| Propanol SCHEMBL2911013 | 0.89 | CRBN (0.62) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| Ethyl Acetate SCHEMBL2913872 | 0.88 | CRBN (0.59) | CRBNCYP3A4BRD4IKBKBCHUK | |
| Acetonitrile SCHEMBL2915375 | 0.87 | CRBN (0.64) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| Isopropyl Alcohol SCHEMBL2910113 | 0.87 | CRBN (0.64) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| SCHEMBL2913565 | 0.86 | CRBN (0.58) | CRBNCYP3A4BRPF1BRD4IKBKB | |
| SCHEMBL3651415 | 0.85 | CRBN (0.52) | CRBNCYP3A4BRPF1BRD4IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-2203431-A1 | ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF | Abbott Laboratories (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009039134-A1 | ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |