Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 9/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 9/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29168391 | 1.00 | KRAS (0.33) | KRASSOS1KMT2AMEN1ROCK2 | |
| SCHEMBL27187226 | 0.87 | SOS1 (0.34) | KRASSOS1KMT2AMEN1ROCK2 | |
| SCHEMBL27187229 | 0.87 | SOS1 (0.34) | KRASSOS1KMT2AMEN1ROCK2 | |
| SCHEMBL27186109 | 0.83 | KRAS (0.36) | KRASSOS1KMT2AMEN1ROCK2 | |
| SCHEMBL27186105 | 0.83 | KRAS (0.36) | KRASSOS1KMT2AMEN1ROCK2 | |
| SCHEMBL27187006 | 0.81 | KRAS (0.35) | KRASSOS1KMT2AMEN1 | |
| SCHEMBL27187007 | 0.81 | KRAS (0.35) | KRASSOS1KMT2AMEN1 | |
| SCHEMBL27186119 | 0.80 | KRAS (0.35) | KRASSOS1KMT2AMEN1ROCK2 | |
| SCHEMBL27186124 | 0.80 | KRAS (0.35) | KRASSOS1KMT2AMEN1ROCK2 | |
| SCHEMBL27186380 | 0.79 | KRAS (0.34) | KRASSOS1KMT2AMEN1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |