Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.48 |
| ▸ | ADH1B | P00325 | 1/20 | 0.48 |
| ▸ | ADH1C | P00326 | 1/20 | 0.48 |
| ▸ | ADH1A | P07327 | 1/20 | 0.48 |
| ▸ | ADH4 | P08319 | 1/20 | 0.48 |
| ▸ | ADH7 | P40394 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28389026 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL28363817 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL3133413 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL15694637 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL7190942 | 0.97 | — | — | |
| SCHEMBL25230203 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL8640187 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL22627533 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL22557627 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B | |
| SCHEMBL5564899 | 0.97 | TSHR (0.63) | TSHRALDH1A1DNM1EPHX1ADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117658933-A | 1,2, 4-triazolol substituted benzenesulfonamide derivatives | 贵阳学院 | 2024-03-08 | — | — | CN | disclosed |