Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | TTK | P33981 | 5/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206122 | 1.00 | LRRK2 (0.42) | LRRK2TTKALKINSRPTK2 | |
| SCHEMBL29173409 | 0.93 | LRRK2 (0.51) | LRRK2TTKALKINSRPTK2 | |
| SCHEMBL30206251 | 0.93 | LRRK2 (0.51) | LRRK2TTKALKINSRPTK2 | |
| SCHEMBL29173445 | 0.92 | ZAP70 (0.43) | LRRK2ALKINSRPTK2MAPK8 | |
| SCHEMBL29173600 | 0.92 | LRRK2 (0.47) | LRRK2TTKALKINSRPTK2 | |
| SCHEMBL30206325 | 0.92 | LRRK2 (0.47) | LRRK2TTKALKINSRPTK2 | |
| SCHEMBL24944156 | 0.92 | MAPK9 (0.40) | LRRK2TTKALKINSRPTK2 | |
| SCHEMBL29173512 | 0.90 | PKMYT1 (0.40) | LRRK2ALKINSRAURKAJAK2 | |
| SCHEMBL30206202 | 0.90 | PKMYT1 (0.40) | LRRK2ALKINSRAURKAJAK2 | |
| SCHEMBL29173608 | 0.87 | PKMYT1 (0.38) | LRRK2ALKINSRAURKAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |