Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 6/20 | 0.64 |
| ▸ | NEK7 | Q8TDX7 | 8/20 | 0.57 |
| ▸ | SRC | P12931 | 5/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | KIF5B | P33176 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | ABL2 | P42684 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | NPM1 | P06748 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29175943 | 0.90 | RIPK2 (0.53) | RIPK2NEK7SRCRETKIF5B | |
| SCHEMBL23966923 | 0.82 | RIPK2 (0.91) | RIPK2NEK7SRCRETKIF5B | |
| SCHEMBL29998925 | 0.82 | RIPK2 (0.91) | RIPK2NEK7SRCRETKIF5B | |
| SCHEMBL23966783 | 0.79 | RIPK2 (0.70) | RIPK2SRCRETKIF5BKDR | |
| SCHEMBL23966929 | 0.78 | NEK7 (0.64) | RIPK2NEK7SRCFLT3 | |
| SCHEMBL29484486 | 0.78 | NEK7 (0.64) | RIPK2NEK7SRCFLT3 | |
| SCHEMBL23966761 | 0.78 | RIPK2 (0.84) | RIPK2SRCRETKIF5BKDR | |
| SCHEMBL2075045 | 0.78 | RIPK2 (0.84) | RIPK2SRCRETKIF5BKDR | |
| SCHEMBL29999326 | 0.78 | RIPK2 (0.84) | RIPK2SRCRETKIF5BKDR | |
| SCHEMBL24072623 | 0.78 | RIPK2 (0.69) | RIPK2NEK7SRCPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597346-A | NEK7 inhibitors | 哈利亚治疗公司 | 2024-02-23 | — | — | CN | disclosed |