Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.39 |
| ▸ | EED | O75530 | 8/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 8/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 8/20 | 0.39 |
| ▸ | AEBP2 | Q6ZN18 | 8/20 | 0.39 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28466809 | 0.85 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13280787 | 0.78 | IDO1 (0.42) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL31729581 | 0.78 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16740904 | 0.78 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL29613562 | 0.76 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13276540 | 0.76 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL29180266 | 0.75 | EZH2 (0.72) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13280809 | 0.73 | GAA (0.43) | IDO1 | |
| SCHEMBL16213153 | 0.73 | EED (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL24072862 | 0.72 | EZH2 (0.47) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197202-B | EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2024-01-26 | — | — | CN | disclosed |