Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2914424 | 0.89 | MAPT (0.41) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL588576 | 0.87 | KMT2A (0.43) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL2918449 | 0.80 | HTR2C (0.47) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL27725837 | 0.80 | MAPT (0.44) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL2919544 | 0.78 | MAPT (0.42) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL2916955 | 0.78 | MAPT (0.45) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL4607882 | 0.76 | MAPT (0.39) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL3009469 | 0.76 | MAPT (0.39) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL2916952 | 0.76 | PDE11A (0.42) | MAPTALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL3026830 | 0.76 | PDE11A (0.43) | MAPTALDH1A1HSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874781-B9 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2010-09-08 | — | — | EP | disclosed |
| EP-1874781-B1 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2009-06-24 | — | — | EP | disclosed |
| EP-2060575-A1 | Dihydrothienopyrimidines and their use in treating inflammatory diseases | Boehringer Ingelheim International GmbH (DE) | 2009-05-20 | — | — | EP | disclosed |
| EP-1874781-A1 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111549-A1 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-10-26 | — | — | WO | disclosed |