Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 18/20 | 0.79 |
| ▸ | CDK2 | P24941 | 11/20 | 0.79 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.79 |
| ▸ | ABL1 | P00519 | 3/20 | 0.79 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.79 |
| ▸ | RET | P07949 | 3/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.79 |
| ▸ | BCR | P11274 | 2/20 | 0.79 |
| ▸ | PLK4 | O00444 | 2/20 | 0.79 |
| ▸ | JAK2 | O60674 | 2/20 | 0.79 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.79 |
| ▸ | LCK | P06239 | 2/20 | 0.79 |
| ▸ | FYN | P06241 | 2/20 | 0.79 |
| ▸ | FES | P07332 | 2/20 | 0.79 |
| ▸ | LYN | P07948 | 2/20 | 0.79 |
| ▸ | SRC | P12931 | 2/20 | 0.79 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.79 |
| ▸ | FER | P16591 | 2/20 | 0.79 |
| ▸ | MARK3 | P27448 | 2/20 | 0.79 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29188478 | 1.00 | AURKA (0.79) | AURKACDK2AURKBABL1NTRK1 | |
| SCHEMBL25649544 | 0.94 | AURKA (0.77) | AURKACDK2AURKBABL1NTRK1 | |
| SCHEMBL1377925 | 0.89 | AURKA (0.86) | AURKACDK2AURKBABL1NTRK1 | |
| SCHEMBL26184014 | 0.89 | AURKA (0.86) | AURKACDK2AURKBABL1NTRK1 | |
| SCHEMBL9998664 | 0.89 | AURKA (0.86) | AURKACDK2AURKBABL1NTRK1 | |
| SCHEMBL25277403 | 0.89 | AURKA (0.86) | AURKACDK2AURKBABL1NTRK1 | |
| Danusertib SCHEMBL466509 | 0.89 | AURKA (1.00) | AURKACDK2AURKBABL1NTRK1 | |
| SCHEMBL1379851 | 0.89 | AURKA (0.85) | AURKACDK2AURKBABL1NTRK1 | |
| Danusertib SCHEMBL2685432 | 0.89 | AURKA (1.00) | AURKACDK2AURKBABL1NTRK1 | |
| SCHEMBL25649539 | 0.88 | AURKA (0.66) | AURKACDK2AURKBABL1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116239566-A | E3 ubiquitin ligase ligand compound, protein degradation agent developed based on ligand compound and application thereof | 标新生物医药科技(上海)有限公司 | 2023-06-09 | — | — | CN | claimed |