Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.74 |
| ▸ | JAK2 | O60674 | 3/20 | 0.74 |
| ▸ | FLT3 | P36888 | 3/20 | 0.74 |
| ▸ | RET | P07949 | 2/20 | 0.74 |
| ▸ | JAK1 | P23458 | 2/20 | 0.74 |
| ▸ | WEE1 | P30291 | 2/20 | 0.74 |
| ▸ | JAK3 | P52333 | 2/20 | 0.74 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.74 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.74 |
| ▸ | BUB1B | O60566 | 1/20 | 0.74 |
| ▸ | BRD2 | P25440 | 1/20 | 0.74 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.74 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.58 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | STK25 | O00506 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31077719 | 1.00 | BRD4 (0.74) | BRD4JAK2FLT3RETJAK1 | |
| SCHEMBL263679 | 0.92 | BRD4 (0.83) | BRD4JAK2FLT3RETJAK1 | |
| SCHEMBL29439990 | 0.92 | BRD4 (0.83) | BRD4JAK2FLT3RETJAK1 | |
| Hydrochloric Acid SCHEMBL264727 | 0.92 | BRD4 (0.81) | BRD4JAK2FLT3RETJAK1 | |
| SCHEMBL25439468 | 0.87 | BRD4 (0.79) | BRD4JAK2FLT3RETJAK1 | |
| SCHEMBL31077704 | 0.87 | BRD4 (0.79) | BRD4JAK2FLT3RETJAK1 | |
| SCHEMBL265602 | 0.87 | BRD4 (0.73) | BRD4JAK2FLT3RETJAK1 | |
| Hydrochloric Acid SCHEMBL264695 | 0.86 | BRD4 (0.72) | BRD4JAK2FLT3RETJAK1 | |
| SCHEMBL271198 | 0.86 | BRD4 (0.85) | BRD4JAK2FLT3RETJAK1 | |
| SCHEMBL263665 | 0.85 | BRD4 (0.84) | BRD4JAK2FLT3RETJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116239566-A | E3 ubiquitin ligase ligand compound, protein degradation agent developed based on ligand compound and application thereof | 标新生物医药科技(上海)有限公司 | 2023-06-09 | — | — | CN | disclosed |