SCHEMBL29190232

SCHEMBL29190232

Cc1ccc(CN(Cc2ccc(C)cc2)C(=O)c2ccccc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 5/20 0.61
HDAC6 Q9UBN7 5/20 0.61
HDAC3 O15379 1/20 0.61
HDAC7 Q8WUI4 1/20 0.61
HDAC10 Q969S8 1/20 0.61
HDAC8 Q9BY41 1/20 0.61
KMT2A Q03164 3/20 0.60
MEN1 O00255 2/20 0.60
L3MBTL1 Q9Y468 1/20 0.58
MAPT P10636 2/20 0.55
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
GAA P10253 1/20 0.54
HPGD P15428 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
POLB P06746 1/20 0.54
CRHBP P24387 1/20 0.53
CRHR2 Q13324 1/20 0.53
LPAR1 Q92633 2/20 0.52
LPAR5 Q9H1C0 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3456064 0.93 KMT2A (0.70) HDAC1HDAC6HDAC3HDAC7HDAC10
SCHEMBL1003508 0.86 HDAC1 (0.71) HDAC1HDAC6HDAC3HDAC7HDAC10
SCHEMBL20218944 0.83 LTB4R2 (0.62) KMT2AMEN1GAANPC1RAB9A
SCHEMBL13166884 0.83 KMT2A (0.68) HDAC1HDAC6HDAC3HDAC7HDAC10
Oxalic Acid SCHEMBL29264737 0.82 HDAC1 (0.67) HDAC1HDAC6HDAC3HDAC7HDAC10
Oxalic Acid SCHEMBL29264739 0.82 HDAC1 (0.67) HDAC1HDAC6HDAC3HDAC7HDAC10
SCHEMBL8359492 0.82 KMT2A (0.76) HDAC1HDAC6HDAC3HDAC7HDAC10
SCHEMBL13911247 0.82 HDAC1 (0.66) HDAC1HDAC6HDAC3KMT2AMEN1
SCHEMBL13900646 0.80 KMT2A (0.55) HDAC1HDAC6HDAC3HDAC7HDAC10
SCHEMBL6843722 0.79 ALDH1A1 (0.68) HDAC1HDAC6HDAC3HDAC7HDAC10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117623975-A Allyl-containing alpha-quaternary carbon secondary amine compound and oxazine compound synthesized by same and containing quaternary carbon center 扬州大学 2024-03-01 CN disclosed