SCHEMBL2919129

SCHEMBL2919129

NC(=O)CCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 18/20 0.67
CRBN Q96SW2 18/20 0.67
IKZF3 Q9UKT9 2/20 0.65
TNF P01375 1/20 0.65
IL1B P01584 1/20 0.65
TBXA2R P21731 1/20 0.65
IKZF1 Q13422 1/20 0.65
ALDH1A1 P00352 1/20 0.58
CHRM2 P08172 1/20 0.58
OPRM1 P35372 1/20 0.58
CYP1A2 P05177 1/20 0.58
TSHR P16473 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
HDAC1 Q13547 1/20 0.51
HDAC2 Q92769 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23272146 0.94 DDB1 (0.64) DDB1CRBNIKZF3TNFIL1B
SCHEMBL20242214 0.90 DDB1 (0.68) DDB1CRBNIKZF3TNFIL1B
SCHEMBL15643263 0.89 DDB1 (0.69) DDB1CRBNIKZF3TNFIL1B
SCHEMBL29259975 0.87 CRBN (0.69) DDB1CRBNIKZF3TNFIL1B
SCHEMBL21227696 0.87 DDB1 (0.70) DDB1CRBNIKZF3TNFIL1B
SCHEMBL30938298 0.87 CRBN (0.69) DDB1CRBNIKZF3TNFIL1B
SCHEMBL25565728 0.87 DDB1 (0.69) DDB1CRBNIKZF3TNFIL1B
SCHEMBL1964279 0.86 DDB1 (0.81) DDB1CRBNIKZF3TNFIL1B
SCHEMBL21759713 0.86 DDB1 (0.66) DDB1CRBNIKZF3TNFIL1B
SCHEMBL26317539 0.85 DDB1 (0.68) DDB1CRBNIKZF3TNFIL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2203176-A2 TUMOR SUPPRESSION USING HUMAN PLACENTAL PERFUSATE AND HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS Celgene Cellular Therapeutics (US) 2010-07-07 EP disclosed
WO-2009045360-A2 TUMOR SUPPRESSION USING HUMAN PLACENTAL PERFUSATE AND HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS CELGENE CELLULAR THERAPEUTICS (US) 2009-04-09 WO disclosed
EP-1974013-A2 IMPROVED COMPOSITION FOR COLLECTING AND PRESERVING PLACENTAL STEM CELLS AND METHODS OF USING THE COMPOSITION Anthrogenesis Corporation (US) 2008-10-01 EP disclosed
EP-1901789-A2 REPAIR OF TYMPANIC MEMBRANE USING PLACENTA DERIVED COLLAGEN BIOFABRIC Anthrogenesis Corporation (US) 2008-03-26 EP disclosed
WO-2007079185-A2 IMPROVED COMPOSITION FOR COLLECTING AND PRESERVING PLACENTAL STEM CELLS AND METHODS OF USING THE COMPOSITION ANTHROGENESIS CORPORATION (US) 2007-07-12 WO disclosed
EP-1767533-A1 N-{(2-(2,6-dioxo(3-piperidyl)-1,3-dioxo-2,3-dihydro-1H-isoindolin-4-yl)methyl}cyclopropylcarboxamide as TNF inhibitor CELGENE CORPORATION (US) 2007-03-28 EP disclosed
WO-2007005807-A2 REPAIR OF TYMPANIC MEMBRANE USING PLACENTA DERIVED COLLAGEN BIOFABRIC ANTHROGENESIS CORPORATION (US) 2007-01-11 WO disclosed
EP-1694328-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT AND MANAGEMENT OF HEMOGLOBINOPATHY AND ANEMIA CELGENE CORPORATION (US) 2006-08-30 EP disclosed
WO-2005055929-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT AND MANAGEMENT OF HEMOGLOBINOPATHY AND ANEMIA CELGENE CORPORATION (US) 2005-06-23 WO disclosed