Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923395 | 0.91 | MAPT (0.52) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| SCHEMBL3757505 | 0.89 | AOC3 (0.47) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| SCHEMBL3757503 | 0.89 | AOC3 (0.47) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| SCHEMBL3757500 | 0.89 | AOC3 (0.47) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| Hydrochloric Acid SCHEMBL3757804 | 0.88 | AOC3 (0.46) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| Hydrochloric Acid SCHEMBL3757799 | 0.88 | AOC3 (0.46) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| Hydrochloric Acid SCHEMBL3757801 | 0.88 | AOC3 (0.46) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| SCHEMBL3751571 | 0.83 | PDE10A (0.51) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| SCHEMBL3751570 | 0.83 | PDE10A (0.51) | SMN1; SMN2MAPTTP53LMNAPOLB | |
| SCHEMBL2940590 | 0.80 | MAPT (0.48) | SMN1; SMN2MAPTTP53THRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222160-A2 | HALOALLYLAMINE INHIBITORS OF SSAO/VAP-1 AND USES THEREFOR | Pharmaxis Ltd. (AU) | 2010-09-01 | — | — | EP | claimed |
| WO-2009066152-A2 | HALOALLYLAMINE INHIBITORS OF SSAO/VAP-1 AND USES THEREFOR | PHARMAXIS LTD. (US) | 2009-05-28 | — | — | WO | claimed |