Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | STK17B | O94768 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916705 | 0.87 | KDR (0.52) | SRCMAPK10JUNSYKJAK2 | |
| SCHEMBL2911814 | 0.83 | MAPK10 (0.53) | STK17AMAPK10JUNSYKPTGS1 | |
| SCHEMBL12999377 | 0.83 | ABL1 (0.58) | SRCSYKAURKACDK4CDK2 | |
| SCHEMBL2912369 | 0.83 | SYK (0.56) | GAASRCSYKJAK2PTGS1 | |
| SCHEMBL2913599 | 0.83 | KDR (0.56) | SYKPTGS1PTGS2AURKACDK1 | |
| SCHEMBL2922769 | 0.83 | SYK (0.67) | GAASRCSYKAURKACDK1 | |
| SCHEMBL12999380 | 0.82 | JAK2 (0.52) | MAPK10JUNJAK2JAK1TYK2 | |
| SCHEMBL12999378 | 0.82 | AURKA (0.60) | SRCMAPK10SYKAURKACDK1 | |
| Hydrochloric Acid SCHEMBL2916265 | 0.82 | ABL1 (0.57) | SRCSYKAURKACDK4CDK2 | |
| SCHEMBL2919987 | 0.81 | STK17A (0.54) | STK17ASTK17BMAPK10JUNSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311965-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | CARNA BIOSCIENCES INC. (JP) | 2010-12-09 | — | — | US | disclosed |
| EP-2226315-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Carna Biosciences Inc. (JP) | 2010-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311965-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | DSTYK, ABL1, EEF2K | L3MBTL1 1868/4885KDM4E 431/4885GAA 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.