Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 15/20 | 0.59 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.59 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29197833 | 0.90 | DDB1 (0.52) | DDB1CRBNGPR119 | |
| SCHEMBL24880998 | 0.88 | CRBN (0.61) | DDB1CRBNPOLB | |
| SCHEMBL29877042 | 0.87 | DDB1 (0.63) | DDB1CRBNGPR119HRH3POLB | |
| SCHEMBL24881088 | 0.87 | DDB1 (0.63) | DDB1CRBNGPR119HRH3POLB | |
| SCHEMBL29197001 | 0.85 | CRBN (0.48) | DDB1CRBNPOLB | |
| SCHEMBL31548077 | 0.84 | DDB1 (0.55) | DDB1CRBN | |
| SCHEMBL29197126 | 0.84 | DDB1 (0.55) | DDB1CRBN | |
| SCHEMBL24319591 | 0.83 | DDB1 (0.58) | DDB1CRBNGPR119HRH3 | |
| SCHEMBL31630961 | 0.81 | DDB1 (0.63) | DDB1CRBNGPR119HRH3 | |
| SCHEMBL31282185 | 0.81 | DDB1 (0.59) | DDB1CRBNGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940133-A | Therapeutic agents for degradation of mutant BRAF | C4医药公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4351583-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 Therapeutics, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022261250-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 THERAPEUTICS, INC. (US) | 2022-12-15 | — | — | WO | disclosed |