Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636431 | 0.86 | KDM4E (0.49) | KDM4ECYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL969557 | 0.86 | KDM4E (0.49) | KDM4ECYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL636430 | 0.86 | KDM4E (0.49) | KDM4ECYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL18663448 | 0.86 | HIF1A (0.39) | KMT2AHSD17B2ALDH1A1 | |
| SCHEMBL23212076 | 0.84 | CYP2D6 (0.45) | CYP2D6HTR2AHTR2CHSD17B2EPHX1 | |
| SCHEMBL27674158 | 0.84 | HSD17B2 (0.41) | HSD17B2 | |
| SCHEMBL5508506 | 0.84 | CHRM3 (0.46) | KDM4ECYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL5508508 | 0.84 | CHRM3 (0.46) | KDM4ECYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL27689759 | 0.84 | CHRM3 (0.46) | KDM4ECYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL23365129 | 0.82 | HSD17B2 (0.46) | TSHRLMNAMAPK1KMT2AHSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117916231-A | Compounds for inhibiting or degrading target proteins, compositions comprising the same, methods of making and methods of using the same | 纽力克斯治疗公司 | 2024-04-19 | — | — | CN | disclosed |