Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.60 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23127382 | 1.00 | CYP3A4 (0.60) | CYP3A4ACESSTR3ATMCTSL | |
| SCHEMBL23127370 | 0.88 | ACE (0.66) | CYP3A4ACESSTR3ATMCTSL | |
| SCHEMBL28555823 | 0.88 | ACE (0.66) | CYP3A4ACESSTR3ATMCTSL | |
| SCHEMBL23100722 | 0.85 | ECE1 (0.49) | CYP3A4CTSL | |
| SCHEMBL23100720 | 0.85 | ECE1 (0.49) | CYP3A4CTSL | |
| SCHEMBL29380695 | 0.81 | MAPT (0.57) | CYP3A4ACESSTR3ATMCTSL | |
| SCHEMBL23127160 | 0.81 | MAPT (0.57) | CYP3A4ACESSTR3ATMCTSL | |
| SCHEMBL25730436 | 0.81 | MAPT (0.57) | CYP3A4ACESSTR3ATMCTSL | |
| SCHEMBL23126850 | 0.80 | SCN9A (0.59) | CYP3A4ACESSTR3ATMCTSL | |
| SCHEMBL23127138 | 0.80 | ACE (0.55) | CYP3A4ACESSTR3ATMCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239948-A | Solid forms and methods of making fused tricyclic compounds, including methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-117946107-A | Solid forms and methods of making fused tricyclic compounds, including methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-04-30 | — | — | CN | disclosed |