Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.59 |
| ▸ | INSR | P06213 | 8/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.52 |
| ▸ | IGF1R | P08069 | 3/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886472 | 0.85 | ALK (0.65) | EGFRALKINSRLRRK2CYP3A4 | |
| SCHEMBL884921 | 0.84 | ALK (0.56) | EGFRALKINSRLRRK2CYP3A4 | |
| SCHEMBL2920216 | 0.76 | ALK (0.62) | EGFRALKINSRLRRK2CYP3A4 | |
| SCHEMBL884776 | 0.75 | ALK (0.73) | EGFRALKINSRLRRK2CYP3A4 | |
| SCHEMBL21846988 | 0.75 | EGFR (1.00) | EGFRLRRK2 | |
| SCHEMBL2061740 | 0.73 | ALK (0.91) | EGFRALKINSRLRRK2CYP3A4 | |
| SCHEMBL4099957 | 0.73 | ZAP70 (0.78) | EGFRALKINSRLRRK2ZAP70 | |
| SCHEMBL2060832 | 0.72 | ALK (0.82) | EGFRALKINSRLRRK2ZAP70 | |
| SCHEMBL886129 | 0.72 | ALK (0.85) | EGFRALKINSRLRRK2CYP3A4 | |
| SCHEMBL26611806 | 0.72 | EGFR (0.77) | EGFRALKINSRLRRK2ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |