Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30322367 | 0.86 | PIK3CA (0.33) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL29202703 | 0.86 | PIK3CA (0.33) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887207 | 0.81 | PIK3CA (0.37) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL30064040 | 0.81 | PIK3CA (0.39) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23887343 | 0.81 | PIK3CA (0.37) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL24913406 | 0.81 | PIK3CA (0.37) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23887051 | 0.81 | PIK3CA (0.39) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL29139166 | 0.77 | PIK3CA (0.40) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL30770733 | 0.76 | PIK3CA (0.34) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL29202685 | 0.76 | PIK3CA (0.34) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117769546-A | Allosteric ketene inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease | 佩特拉制药公司 | 2024-03-26 | — | — | CN | disclosed |