Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | BCL6 | P41182 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30232265 | 1.00 | CYP1A2 (0.53) | CYP1A2BCL6CNR1CNR2MAPT | |
| SCHEMBL29203264 | 1.00 | CYP1A2 (0.53) | CYP1A2BCL6CNR1CNR2MAPT | |
| SCHEMBL23357569 | 0.91 | CYP1A2 (0.63) | CYP1A2BCL6CNR1CNR2MAPT | |
| SCHEMBL20569854 | 0.87 | CYP1A2 (0.51) | CYP1A2BCL6CNR1CNR2MAPT | |
| SCHEMBL31520705 | 0.86 | CYP1A2 (0.58) | CYP1A2BCL6CNR1CNR2MAPT | |
| SCHEMBL20568778 | 0.83 | CYP1A2 (0.53) | CYP1A2BCL6PKM | |
| SCHEMBL31521004 | 0.83 | CYP1A2 (0.53) | CYP1A2BCL6MAPTATMPOLB | |
| SCHEMBL29203270 | 0.81 | KDM4E (0.48) | BCL6CNR1CNR2MAPTALDH1A1 | |
| SCHEMBL29203274 | 0.81 | KDM4E (0.48) | BCL6CNR1CNR2MAPTALDH1A1 | |
| SCHEMBL30232262 | 0.81 | KDM4E (0.48) | BCL6CNR1CNR2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380919-A1 | CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS | Dana-Farber Cancer Institute, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117980290-A | Cyanopyridine and cyanopyrimidine BCL6 degrading agents | 达纳－法伯癌症研究所公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023015164-A1 | CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-02-09 | — | — | WO | disclosed |