⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245620 | 0.70 | — | — | |
| SCHEMBL9216583 | 0.69 | — | — | |
| SCHEMBL10726868 | 0.66 | — | — | |
| SCHEMBL11627946 | 0.66 | — | — | |
| SCHEMBL22534262 | 0.66 | — | — | |
| SCHEMBL6852037 | 0.64 | — | — | |
| SCHEMBL21311233 | 0.64 | TLR8 (0.31) | — | |
| SCHEMBL22534261 | 0.61 | — | — | |
| SCHEMBL1067525 | 0.58 | — | — | |
| SCHEMBL292468 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100577658-C | Quinazoline derivatives | ASTRAZENECA AB | 2010-01-06 | — | — | CN | claimed |
| EP-2091929-A1 | AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS | The European Molecular Biology Laboratory (DE) | 2009-08-26 | — | — | EP | claimed |
| CN-101421257-A | Agents that disrupt cellular replication and their use in inhibiting pathological conditions | EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE) | 2009-04-29 | — | — | CN | claimed |
| WO-2007107352-A1 | AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS | THE EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2007-09-27 | — | — | WO | claimed |
| JP-2007506716-A | — | — | 2007-03-22 | — | — | JP | claimed |
| US-20070043010-A1 | Quinazoline derivatives | ASTRAZENECA UK LIMITED (GB) | 2007-02-22 | — | — | US | claimed |
| CN-1886399-A | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | CN | claimed |
| EP-1670786-A1 | QUINAZOLINE DERIVATIVES | Astrazeneca AB (SE) | 2006-06-21 | — | — | EP | claimed |
| WO-2005030757-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | claimed |
| US-11890296-B2 | Anti-tumor agent containing cytarabine, anti- tumor effect enhancing agent which is used in combination with cytarabine, anti-tumor kit, and anti-tumor agent which is used in combination with cytarabine | FUJIFILM CORPORATION (JP) | 2024-02-06 | — | — | US | disclosed |
| CN-106458904-B | N-substituted sulfonamide compound and process for producing the same | 宇部兴产株式会社 | 2021-12-03 | — | — | CN | disclosed |
| EP-3858361-A1 | ANTITUMOR AGENT CONTAINING CYTARABINE, ANTITUMOR EFFECT ENHANCER USED IN COMBINATION WITH CYTARABINE, ANTITUMOR KIT, AND ANTITUMOR AGENT USED IN COMBINATION WITH CYTARABINE | FUJIFILM Corporation (JP) | 2021-08-04 | — | — | EP | disclosed |
| EP-3156396-B1 | METHOD FOR PRODUCING A N-SUBSTITUTED SULFONAMIDE COMPOUND | UBE INDUSTRIES (JP) | 2021-07-21 | — | — | EP | disclosed |
| US-20210213040-A1 | ANTI-TUMOR AGENT CONTAINING CYTARABINE, ANTI-TUMOR EFFECT ENHANCING AGENT WHICH IS USED IN COMBINATION WITH CYTARABINE, ANTI-TUMOR KIT, AND ANTI-TUMOR AGENT WHICH IS USED IN COMBINATION WITH CYTARABINE | FUJIFILM CORPORATION (JP) | 2021-07-15 | — | — | US | disclosed |
| EP-0170192-A1 | Penicillin derivatives as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1986-02-05 | — | — | EP | disclosed |
| US-4547371-A | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO., INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4472309-A | ANTIMICROBIAL | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-09-18 | — | — | US | disclosed |
| US-4304718-A | ANTIBIOTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-08 | — | — | US | disclosed |
| US-4264498-A | REACTED WITH AN ACID, ITS ACID HALIDE, OR ANHYDRIDE IN THE PRESENCE OF BORON TRIHALIDE AND AN ORGANIC BASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-04-28 | — | — | US | disclosed |
| US-4181800-A | ANTIBIOTICS FROM SUBSTITUTED PERHYDRO-S-TRIAZINES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-01-01 | — | — | US | disclosed |