Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003106 | 0.85 | EPHX2 (0.46) | USP2SMN1; SMN2EPHX2EPHX1HPGD | |
| SCHEMBL1586974 | 0.82 | EPHX2 (0.43) | USP2SMN1; SMN2EPHX2EPHX1MMP13 | |
| SCHEMBL22770533 | 0.81 | KDM4E (0.46) | USP2SMN1; SMN2EPHX2EPHX1HPGD | |
| SCHEMBL18319088 | 0.81 | EPHX2 (0.42) | USP2SMN1; SMN2EPHX2EPHX1TSHR | |
| SCHEMBL18418212 | 0.81 | USP2 (0.50) | USP2SMN1; SMN2EPHX2EPHX1HPGD | |
| SCHEMBL4778809 | 0.80 | EPHX2 (0.39) | USP2SMN1; SMN2EPHX2ADAM17 | |
| SCHEMBL19625229 | 0.80 | EPHX2 (0.39) | USP2SMN1; SMN2EPHX2NAMPTMMP13 | |
| SCHEMBL12113151 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2EPHX2EPHX1HPGD | |
| SCHEMBL1586924 | 0.80 | USP2 (0.49) | USP2SMN1; SMN2EPHX2EPHX1HPGD | |
| SCHEMBL154164 | 0.80 | USP2 (0.49) | USP2SMN1; SMN2EPHX2EPHX1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4463231-A1 | RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-11-20 | — | — | EP | disclosed |
| CN-118234731-A | RAS inhibitors | 锐新医药公司 | 2024-06-21 | — | — | CN | disclosed |
| EP-4346898-A1 | METHODS FOR INHIBITING RAS | Revolution Medicines, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117715658-A | Method for inhibiting RAS | 锐新医药公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-4334321-A1 | RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2023133543-A1 | RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-07-13 | — | — | WO | disclosed |
| WO-2022251292-A1 | METHODS FOR INHIBITING RAS | Revolution Medicines, Inc. (US) | 2022-12-01 | — | — | WO | disclosed |
| WO-2022235864-A1 | RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2022-11-10 | — | — | WO | disclosed |