Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 11/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.48 |
| ▸ | CDK4 | P11802 | 4/20 | 0.48 |
| ▸ | CCND1 | P24385 | 4/20 | 0.48 |
| ▸ | CCND3 | P30281 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29212666 | 0.87 | DYRK2 (0.71) | DYRK2CDK6 | |
| SCHEMBL29212669 | 0.84 | DYRK2 (0.72) | DYRK2CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL31472289 | 0.84 | CDK2 (0.58) | DYRK2CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL29233639 | 0.84 | CDK2 (0.58) | DYRK2CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL30883983 | 0.82 | DYRK2 (0.64) | DYRK2CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL29212665 | 0.82 | DYRK2 (0.64) | DYRK2CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL30569710 | 0.81 | DYRK2 (0.74) | DYRK2CDK6CDK4CCND1CCND3 | |
| SCHEMBL26451650 | 0.81 | DYRK2 (0.74) | DYRK2CDK6CDK4CCND1CCND3 | |
| SCHEMBL31472288 | 0.80 | CDK2 (0.66) | DYRK2CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL29233646 | 0.80 | CDK2 (0.66) | DYRK2CCNE1CDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005624-A | Pyrimidine benzo five-membered ring CDK inhibitor and preparation method and application thereof | 中国药科大学 | 2024-05-10 | — | — | CN | disclosed |