SCHEMBL2921332

SCHEMBL2921332

NC(=O)CN1Cc2n[nH]c(NC(=O)Cc3ccc(N4CCCC4=O)cc3)c2C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.49
MAPK9 P45984 1/20 0.49
MAPK10 P53779 1/20 0.49
CDK2 P24941 3/20 0.47
CCNA2 P20248 1/20 0.47
CCNA1 P78396 1/20 0.47
CACNA1G O43497 1/20 0.43
CACNA1I Q9P0X4 1/20 0.43
F10 P00742 2/20 0.39
PSMB5 P28074 2/20 0.38
USP2 O75604 1/20 0.37
MAPT P10636 4/20 0.37
ALDH1A1 P00352 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
POLB P06746 1/20 0.37
RECQL P46063 1/20 0.37
RAB9A P51151 1/20 0.37
TNIK Q9UKE5 2/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2920683 0.87 CDK2 (0.53) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL2924801 0.86 MAPT (0.45) CDK2CCNA2CCNA1USP2MAPT
SCHEMBL2920265 0.84 CDK2 (0.64) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL2916001 0.84 CDK2 (0.55) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL2944869 0.82 CDK2 (0.51) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL2920533 0.80 CDK2 (0.51) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL4239632 0.79 MAPK8 (0.46) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL2920430 0.79 CDK2 (0.48) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL2922422 0.77 MAPT (0.49) MAPK8MAPK9MAPK10CDK2CCNA2
SCHEMBL2916750 0.75 CDK2 (0.46) MAPK8MAPK9MAPK10CDK2CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1320531-B1 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PFIZER ITALIA SRL (IT) 2010-09-08 EP claimed