⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2267011 | 1.00 | — | — | |
| SCHEMBL2268664 | 1.00 | — | — | |
| SCHEMBL9469864 | 0.77 | DPP4 (0.38) | — | |
| SCHEMBL9469863 | 0.77 | DPP4 (0.38) | — | |
| SCHEMBL1657418 | 0.77 | CHRM2 (0.34) | — | |
| SCHEMBL1657421 | 0.77 | CHRM2 (0.34) | — | |
| SCHEMBL7742934 | 0.73 | DPP4 (0.44) | — | |
| SCHEMBL2922028 | 0.73 | CHRM2 (0.38) | — | |
| SCHEMBL9469289 | 0.73 | ACACB (0.36) | — | |
| SCHEMBL2922032 | 0.73 | CHRM2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481709-B2 | Boropeptide inhibitors of enteropeptidase and their uses in treatment of obesity, overweight and/or diseases associated with an abnormal fat metabolism | OBE THERAPY BIOTECHNOLOGY (FR) | 2016-11-01 | — | — | US | disclosed |
| US-20140187479-A1 | BOROPEPTIDE INHIBITORS OF ENTEROPEPTIDASE AND THEIR USES IN TREATMENT OF OBESITY, OVERWEIGHT AND/OR DISEASES ASSOCIATED WITH AN ABNORMAL FAT METABOLISM | OBE THERAPY BIOTECHNOLOGY (FR) | 2014-07-03 | — | — | US | disclosed |
| US-20100311690-A1 | BOROPEPTIDE INHIBITORS OF ENTEROPEPTIDASE AND THEIR USES IN TREATMENT OF OBESITY, OVERWEIGHT AND/OR DISEASES ASSOCIATED WITH AN ABNORMAL FAT METABOLISM | OBE THERAPY BIOTECHNOLOGY (FR) | 2010-12-09 | — | — | US | disclosed |
| EP-2225261-A1 | BOROPEPTIDE INHIBITORS OF ENTEROPEPTIDASE AND THEIR USES IN TREATMENT OF OBESITY, OVERWEIGHT AND/OR DISEASES ASSOCIATED WITH AN ABNORMAL FAT METABOLISM | OBE THERAPY BIOTECHNOLOGY (FR) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009071601-A1 | BOROPEPTIDE INHIBITORS OF ENTEROPEPTIDASE AND THEIR USES IN TREATMENT OF OBESITY, OVERWEIGHT AND/OR DISEASES ASSOCIATED WITH AN ABNORMAL FAT METABOLISM | OBE THERAPY BIOTECHNOLOGY (FR) | 2009-06-11 | — | — | WO | disclosed |
| US-5217713-A | Anticancer agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-08 | — | — | US | disclosed |
| US-5141736-A | Complexed with ansamitocin | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0376176-A2 | Bispecific monoclonal antibody, its production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |
| EP-0065730-B1 | 9-THIOMAYTANSINOIDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1986-09-10 | — | — | EP | disclosed |
| US-4424219-A | ANTITUMOR AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-01-03 | — | — | US | disclosed |
| US-4371533-A | ANTITUMOR, ANTIPROTOZOA AND ANTIFUNGAL AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-02-01 | — | — | US | disclosed |
| EP-0065730-A1 | 9-Thiomaytansinoids, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1982-12-01 | — | — | EP | disclosed |
| EP-0049528-A1 | 4,5-Deoxymaytansinoids, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1982-04-14 | — | — | EP | disclosed |
| US-4256746-A | ANTITUMOR AGENTS; MICROBIOCIDES; MITOSIS | TAKEDA CHEMICAL INDUSTRIES (JP) | 1981-03-17 | — | — | US | disclosed |
| EP-0011277-A1 | Dechloromaytansinoids, their production and use and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-05-28 | — | — | EP | disclosed |