Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.34 |
| ▸ | ITGAL | P20701 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24810612 | 1.00 | LRRK2 (0.39) | LRRK2EGFRACACBGRIA1HRH4 | |
| SCHEMBL29214582 | 1.00 | LRRK2 (0.39) | LRRK2EGFRACACBGRIA1HRH4 | |
| SCHEMBL30438091 | 0.82 | LRRK2 (0.44) | LRRK2ACACBHRH4ITGB2ICAM1 | |
| SCHEMBL30438430 | 0.82 | LRRK2 (0.44) | LRRK2ACACBHRH4ITGB2ICAM1 | |
| SCHEMBL21333541 | 0.82 | LRRK2 (0.44) | LRRK2ACACBHRH4ITGB2ICAM1 | |
| SCHEMBL21345793 | 0.82 | LRRK2 (0.44) | LRRK2ACACBHRH4ITGB2ICAM1 | |
| SCHEMBL21333053 | 0.82 | LRRK2 (0.44) | LRRK2ACACBHRH4ITGB2ICAM1 | |
| SCHEMBL24811561 | 0.80 | EGFR (0.41) | LRRK2EGFRACACBHRH4ITGB2 | |
| SCHEMBL29083734 | 0.79 | LRRK2 (0.42) | LRRK2ACACBHRH4ITGB2ICAM1 | |
| SCHEMBL24809050 | 0.77 | LRRK2 (0.40) | LRRK2ACACBHRH4ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117836286-A | Heterocyclic EGFR inhibitors for the treatment of cancer | 缆图药品公司 | 2024-04-05 | — | — | CN | disclosed |