Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.46 |
| ▸ | FLT3 | P36888 | 6/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 7/20 | 0.45 |
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.45 |
| ▸ | NEK6 | Q9HC98 | 3/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29227002 | 0.94 | PLK1 (0.48) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226279 | 0.92 | PLK1 (0.51) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226351 | 0.89 | PLK1 (0.43) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL30900352 | 0.88 | PLK1 (0.46) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226218 | 0.88 | PLK1 (0.46) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226195 | 0.87 | PLK1 (0.42) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL30900393 | 0.87 | PLK1 (0.42) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226383 | 0.85 | PLK1 (0.51) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226263 | 0.85 | PLK1 (0.51) | PLK1FLT3PLK3PLK2NEK6 | |
| SCHEMBL29226289 | 0.83 | ALK (0.47) | CCNA2CDK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117658987-A | Compounds as PLK1 inhibitors, and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-03-08 | — | — | CN | disclosed |