SCHEMBL29226504

SCHEMBL29226504

COc1ccc([C@@](C)(O)c2ccc(C)nc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.41
AHR P35869 1/20 0.39
MAPT P10636 1/20 0.38
PSMB1 P20618 1/20 0.38
PSMB5 P28074 1/20 0.38
PSMB2 P49721 1/20 0.38
HSD11B1 P28845 1/20 0.38
CYP19A1 P11511 1/20 0.38
KMT2A Q03164 3/20 0.37
ATM Q13315 2/20 0.37
ALDH1A1 P00352 2/20 0.37
LMNA P02545 1/20 0.37
ALOX15 P16050 1/20 0.37
APEX1 P27695 1/20 0.37
MAPK1 P28482 1/20 0.37
RECQL P46063 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
MEN1 O00255 2/20 0.37
KIT P10721 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30927963 1.00 AOC3 (0.41) AOC3AHRMAPTPSMB1PSMB5
SCHEMBL29226506 1.00 AOC3 (0.41) AOC3AHRMAPTPSMB1PSMB5
SCHEMBL29226521 0.82 MEN1 (0.44) AOC3AHRMAPTPSMB1PSMB5
SCHEMBL29226462 0.82 AOC3 (0.40) AOC3AHRMAPTPSMB1PSMB5
SCHEMBL29226520 0.82 MEN1 (0.44) AOC3AHRMAPTPSMB1PSMB5
SCHEMBL29226458 0.82 AOC3 (0.40) AOC3AHRMAPTPSMB1PSMB5
SCHEMBL7128923 0.82 CA1 (0.55) AOC3MAPTPSMB1PSMB5PSMB2
SCHEMBL12187435 0.81 CYP3A4 (0.42) CYP19A1KMT2AATMALDH1A1ALOX15
SCHEMBL30927957 0.79 CYP19A1 (0.53) CYP19A1KMT2AALDH1A1CYP3A4POLB
SCHEMBL30927949 0.79 CYP19A1 (0.53) CYP19A1KMT2AALDH1A1CYP3A4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117924156-A Synthesis method of aza-aryl alcohol compound and chiral alpha-hydroxycarboxylic acid 赣南师范大学 2024-04-26 CN disclosed