Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB9 | P28065 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 8/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 3/20 | 0.33 |
| ▸ | BIRC3 | Q13489 | 3/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30341240 | 1.00 | PSMB9 (0.39) | PSMB9CFDDRD2CCR5XIAP | |
| SCHEMBL26815961 | 1.00 | PSMB9 (0.39) | PSMB9CFDDRD2CCR5XIAP | |
| SCHEMBL29230582 | 0.95 | PSMB9 (0.40) | PSMB9CFDDRD2XIAPBIRC3 | |
| SCHEMBL24664620 | 0.95 | PSMB9 (0.40) | PSMB9CFDDRD2XIAPBIRC3 | |
| SCHEMBL24666301 | 0.93 | PSMB9 (0.39) | PSMB9CFDDRD2XIAPBIRC3 | |
| SCHEMBL29230876 | 0.92 | PSMB9 (0.37) | PSMB9CFDDRD2XIAPBIRC3 | |
| SCHEMBL24665812 | 0.92 | PSMB9 (0.41) | PSMB9CFDDRD2XIAPBIRC3 | |
| SCHEMBL29231148 | 0.92 | PSMB9 (0.41) | PSMB9CFDDRD2XIAPBIRC3 | |
| SCHEMBL24666415 | 0.91 | CACNA2D1 (0.39) | PSMB9CFDDRD2XIAPBIRC3 | |
| SCHEMBL24666414 | 0.91 | PSMB9 (0.37) | PSMB9CFDDRD2CCR5XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117956985-A | Inhibitors of glycogen synthase 1 (GYS 1) and methods of use thereof | 梅兹治疗公司 | 2024-04-30 | — | — | CN | disclosed |
| EP-4308095-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | Maze Therapeutics, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |