Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | GRM5 | P41594 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GCK | P35557 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31027176 | 1.00 | MAPT (0.59) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31027175 | 0.89 | MAPT (0.57) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30300345 | 0.89 | GRM5 (0.57) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29236353 | 0.89 | MAPT (0.57) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30300303 | 0.87 | MAPT (0.54) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31318875 | 0.87 | MAPT (0.54) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1794081 | 0.83 | NPC1 (0.58) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30761185 | 0.82 | NPC1 (0.62) | MAPTGRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31318883 | 0.82 | MAPT (0.50) | MAPTRAB9ANPC1KDM4EGAA | |
| SCHEMBL31318881 | 0.81 | MAPT (0.51) | MAPTRAB9ANPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118234718-A | Phenyl core compounds as MGLU5 negative allosteric modulators and methods of making and using the same | 范德比尔特大学 | 2024-06-21 | — | — | CN | disclosed |