Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922801 | 0.94 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2921489 | 0.94 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2924793 | 0.94 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2925030 | 0.94 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2914012 | 0.94 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2921320 | 0.93 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL5510122 | 0.93 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2921316 | 0.93 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2916927 | 0.93 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2915710 | 0.93 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTCYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863803-B1 | SUBSTITUTED PIPERIDINES | NOVARTIS AG (CH) | 2010-09-01 | — | — | EP | disclosed |