Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.59 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | STS | P08842 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PTPRB | P23467 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29243776 | 1.00 | JAK2 (0.66) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL18081469 | 0.94 | JAK2 (0.62) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL24424432 | 0.93 | JAK2 (0.61) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL31737363 | 0.93 | JAK2 (0.61) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL3012474 | 0.93 | JAK2 (0.62) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL23555641 | 0.92 | JAK2 (0.60) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL12122824 | 0.90 | JAK2 (0.58) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL23127283 | 0.90 | JAK2 (0.58) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL12122810 | 0.89 | JAK2 (0.57) | JAK2JAK1USP30NR1D1HSD11B1 | |
| SCHEMBL8111282 | 0.89 | JAK2 (0.78) | JAK2JAK1USP30NR1D1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240736-A1 | PPAR GAMMA MODULATORS AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2023-09-13 | — | — | EP | disclosed |
| CN-116635380-A | PPARgamma modulators and methods of use | 卫材R&D管理有限公司 | 2023-08-22 | — | — | CN | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |