Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.54 |
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.54 |
| ▸ | ITK | Q08881 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916720 | 0.85 | SYK (0.41) | AURKAAURKBGSK3BSRCGSK3A | |
| SCHEMBL2919416 | 0.83 | AURKA (0.38) | AURKAAURKBGSK3BSRCGSK3A | |
| SCHEMBL1268774 | 0.83 | PAK4 (0.48) | AURKAAURKBGSK3BSRCGSK3A | |
| SCHEMBL1299269 | 0.80 | AURKA (0.43) | AURKAAURKBGSK3BSRCGSK3A | |
| SCHEMBL2918010 | 0.78 | AURKA (0.37) | AURKAAURKBGSK3BSRCGSK3A | |
| SCHEMBL13221083 | 0.78 | GSK3B (0.53) | AURKAAURKBGSK3BSRCGSK3A | |
| SCHEMBL2148867 | 0.77 | AURKA (0.47) | AURKAAURKBGSK3BSRC | |
| SCHEMBL3114466 | 0.75 | JAK2 (0.39) | AURKAAURKBGSK3BSRCGSK3A | |
| SCHEMBL1722352 | 0.75 | JAK2 (0.58) | AURKASRCPLK4PAK4 | |
| SCHEMBL3028207 | 0.75 | GSK3B (0.55) | AURKAAURKBGSK3BSRCGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812439-B2 | KINASE INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2017-12-06 | — | — | EP | claimed |
| EP-1812439-B1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2010-09-01 | — | — | EP | claimed |
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | claimed |
| JP-2008516973-A | — | — | 2008-05-22 | — | — | JP | claimed |
| EP-1812439-A2 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006044687-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-04-27 | — | — | WO | claimed |
| US-20060084650-A1 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-20 | — | — | US | claimed |
| EP-1812439-B2 | KINASE INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2017-12-06 | — | — | EP | disclosed |
| US-8288536-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-10-16 | — | — | US | disclosed |
| EP-1812439-B1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2010-09-01 | — | — | EP | disclosed |
| US-20100216765-A1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | US | disclosed |
| US-7713973-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-11 | — | — | US | disclosed |
| EP-1812439-A2 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044687-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-04-27 | — | — | WO | disclosed |
| US-20060084650-A1 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084650-A1 | Kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | AURKA 161/4885AURKB 122/4885GSK3B 200/4885 |
| US-20100216765-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K1 | AURKA 161/4885AURKB 122/4885GSK3B 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.