⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169306 | 0.88 | — | — | |
| SCHEMBL7950822 | 0.86 | — | — | |
| SCHEMBL23579427 | 0.75 | — | — | |
| SCHEMBL23367511 | 0.69 | — | — | |
| SCHEMBL4297297 | 0.69 | — | — | |
| SCHEMBL1426645 | 0.69 | — | — | |
| SCHEMBL6535094 | 0.69 | — | — | |
| SCHEMBL1426248 | 0.67 | — | — | |
| SCHEMBL20221292 | 0.66 | — | — | |
| SCHEMBL5745575 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12172989-B2 | Histone acetyltransferase (HAT) inhibitor and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2024-12-24 | — | — | US | disclosed |
| EP-3782995-B1 | SPIRO CONDENSED IMIDAZOLINE-2,4-DIONE DERIVATIVES AS HISTONE ACETYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2023-11-22 | — | — | EP | disclosed |
| CN-110386927-B | Histone Acetyltransferase (HAT) inhibitors and uses thereof | 中国科学院上海药物研究所 | 2022-09-23 | — | — | CN | disclosed |
| US-20220002278-A9 | HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF | SUZHOU INSTITUTE OF MATERIA MEDICA (CN) | 2022-01-06 | — | — | US | disclosed |
| CN-109438418-B | Apoptosis signal-regulating kinase inhibitors | 吉利德科学公司 | 2021-04-13 | — | — | CN | disclosed |
| US-20210101891-A1 | HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-04-08 | — | — | US | disclosed |
| EP-3782995-A1 | HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-02-24 | — | — | EP | disclosed |
| EP-1179595-B1 | (R)-2-OCTANOL DEHYDROGENASES, METHODS FOR PRODUCING THE ENZYMES, DNA ENCODING THE ENZYMES, AND METHODS FOR PRODUCING ALCOHOLS USING THE ENZYMES | DAICEL CHEM (JP) | 2010-09-01 | — | — | EP | disclosed |
| US-7202069-B2 | (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2007-04-10 | — | — | US | disclosed |
| US-7019110-B2 | Streptogramin derivatives, preparation method and compositions containing same | AVENTIS PHARMA S.A. (FR) | 2006-03-28 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |
| CN-1168135-A | Substituted 2-phenylpyridines | BASF AG (DE) | 1997-12-17 | — | — | CN | disclosed |
| EP-0708090-A1 | Intermediates useful for the synthesis of pesticides | RHONE-POULENC AGROCHIMIE (FR) | 1996-04-24 | — | — | EP | disclosed |
| EP-0626966-A1 | 3-SUBSTITUTED IMIDAZO(1,5-A)QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1994-12-07 | — | — | EP | disclosed |
| EP-0355353-B1 | Cycloalkylthiazole derivatives | HOFFMANN LA ROCHE (CH) | 1994-03-16 | — | — | EP | disclosed |
| WO-1993017025-A1 | 3-SUBSTITUTED IMIDAZO(1,5-A)QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY | THE UPJOHN COMPANY (US) | 1993-09-02 | — | — | WO | disclosed |
| US-5001140-A | Cycloalkylthiazoles | HOFFMANN-LA ROCHE INC. (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0355353-A2 | Cycloalkylthiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-02-28 | — | — | EP | disclosed |
| EP-0354757-A2 | Cephalosporins and homologous compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-02-14 | — | — | EP | disclosed |