Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.38 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257611 | 0.86 | IRAK4 (0.41) | IRAK4KCNJ5FGFR1MKNK1 | |
| SCHEMBL24257746 | 0.81 | ABL1 (0.40) | IRAK4KCNJ5LRRK2METCCNE1 | |
| SCHEMBL24257689 | 0.80 | IRAK4 (0.44) | IRAK4LRRK2MAP3K7TAB1MET | |
| SCHEMBL29248950 | 0.79 | IRAK4 (0.57) | IRAK4KCNJ5ACVR1LRRK2MAP3K7 | |
| Nitrous Acid SCHEMBL29248905 | 0.78 | IRAK4 (0.42) | IRAK4LRRK2MAP3K7TAB1MET | |
| Glycine SCHEMBL29248906 | 0.77 | IRAK4 (0.41) | IRAK4LRRK2MAP3K7TAB1MET | |
| SCHEMBL26259620 | 0.75 | EGLN1 (0.44) | ACVR1LRRK2MAP3K7TAB1 | |
| SCHEMBL29248903 | 0.74 | IRAK4 (0.41) | IRAK4ACVR1LRRK2MAP3K7TAB1 | |
| SCHEMBL24257737 | 0.72 | IRAK4 (0.47) | IRAK4KCNJ5LRRK2METALK | |
| SCHEMBL17764645 | 0.71 | IRAK4 (0.61) | IRAK4KCNJ5LRRK2METALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |