Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cc-401. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 known ✓ | P45983 | 1/20 | 0.98 |
| ▸ | MAPK9 known ✓ | P45984 | 1/20 | 0.98 |
| ▸ | MAPK10 known ✓ | P53779 | 1/20 | 0.98 |
| ▸ | CLK2 | P49760 | 3/20 | 0.98 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.98 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.98 |
| ▸ | GAK | O14976 | 1/20 | 0.98 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.98 |
| ▸ | JAK2 | O60674 | 1/20 | 0.98 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.98 |
| ▸ | NQO2 | P16083 | 1/20 | 0.98 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.98 |
| ▸ | FECH | P22830 | 1/20 | 0.98 |
| ▸ | JAK1 | P23458 | 1/20 | 0.98 |
| ▸ | TYK2 | P29597 | 1/20 | 0.98 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.98 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.98 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.98 |
| ▸ | CLK1 | P49759 | 1/20 | 0.98 |
| ▸ | GSK3B | P49841 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cc-401 SCHEMBL29538788 | 1.00 | CLK2 (0.98) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| Cc-401 SCHEMBL23924447 | 1.00 | CLK2 (0.98) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| Cc-401 SCHEMBL29403560 | 1.00 | CLK2 (0.98) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| Cc-401 SCHEMBL30198024 | 1.00 | CLK2 (0.98) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| Cc-401 SCHEMBL30290855 | 0.99 | CLK2 (1.00) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| SCHEMBL8253744 | 0.99 | CLK2 (1.00) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| Cc-401 SCHEMBL4604749 | 0.99 | CLK2 (1.00) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| SCHEMBL5373334 | 0.98 | CLK2 (0.98) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| SCHEMBL5375716 | 0.94 | CLK2 (0.91) | CLK2DYRK1AMAP4K4GAKDYRK3 | |
| SCHEMBL5372579 | 0.91 | CLK2 (0.84) | CLK2DYRK1AMAP4K4GAKDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118318033-A | Cell aggregate comprising pituitary hormone-producing cells and method for producing the same | 住友制药株式会社 | 2024-07-09 | — | — | CN | disclosed |
| CN-118043447-A | Method for preparing cell population containing pituitary tissue and cell population | 住友化学株式会社 | 2024-05-14 | — | — | CN | disclosed |