Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.59 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31155376 | 0.94 | EGFR (0.64) | EGFRBTKALKINSRIGF1R | |
| SCHEMBL29257776 | 0.93 | EGFR (0.61) | EGFRBTKMAP4K1 | |
| SCHEMBL29257836 | 0.91 | EGFR (0.73) | EGFRBTKMAP4K1ALKINSR | |
| SCHEMBL29257850 | 0.91 | EGFR (0.59) | EGFRBTKMAP4K1ALKINSR | |
| SCHEMBL31155401 | 0.89 | EGFR (0.57) | EGFRBTKALKINSRIGF1R | |
| SCHEMBL31155499 | 0.88 | EGFR (0.56) | EGFRBTKALKINSRIGF1R | |
| Hydrochloric Acid SCHEMBL31155447 | 0.88 | EGFR (0.56) | EGFRBTKALKINSRIGF1R | |
| SCHEMBL29257921 | 0.87 | EGFR (0.56) | EGFRBTK | |
| SCHEMBL29094520 | 0.86 | EGFR (0.63) | EGFRBTKMAP4K1 | |
| SCHEMBL25001408 | 0.85 | EGFR (0.64) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888108-B | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116888108-A | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022194269-A1 | NOVEL EGFR DEGRADATION AGENT | 上海齐鲁制药研究中心有限公司 | 2022-09-22 | — | — | WO | disclosed |