Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930395 | 1.00 | MAPT (0.42) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2924639 | 0.93 | PDE4D (0.45) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2928459 | 0.92 | PDE4B (0.44) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2926137 | 0.90 | PDE4B (0.45) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2929410 | 0.88 | PDE4D (0.40) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2931797 | 0.86 | PDE4D (0.47) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2929288 | 0.85 | PDE4D (0.42) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2928952 | 0.84 | PDE4D (0.39) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL1157789 | 0.83 | PDE4B (0.38) | MAPTLMNAPOLBKMT2APDE4B | |
| SCHEMBL2927645 | 0.81 | PDE4B (0.48) | MAPTLMNAPOLBKMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-B1 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARM CORP (US) | 2010-09-15 | — | — | EP | claimed |