Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 8/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | NNMT | P40261 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22773723 | 0.84 | GPR183 (0.62) | GPR183KCNH2HRH3NNMTHPGD | |
| SCHEMBL5909228 | 0.82 | AKR1C1 (0.54) | HRH3AKR1C1 | |
| SCHEMBL19225793 | 0.81 | SMN1; SMN2 (0.65) | GPR183KCNH2NNMTHPGD | |
| SCHEMBL26487454 | 0.81 | HRH3 (0.60) | GPR183KCNH2HRH3NNMTHPGD | |
| SCHEMBL20070482 | 0.80 | HRH3 (0.69) | GPR183KCNH2HRH3NNMTHPGD | |
| SCHEMBL29259402 | 0.79 | HPGD (0.69) | GPR183AKR1C1HPGD | |
| SCHEMBL23126259 | 0.78 | GPR183 (0.59) | GPR183KCNH2HRH3NNMTHPGD | |
| SCHEMBL22812071 | 0.77 | GPR183 (0.58) | GPR183KCNH2HRH3NNMTHPGD | |
| SCHEMBL22031223 | 0.77 | HRH3 (0.71) | GPR183KCNH2HRH3NNMTHPGD | |
| SCHEMBL20070486 | 0.77 | HRH3 (0.67) | GPR183KCNH2HRH3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201911-A | Compounds and their use as GPR183 inhibitors | 南京艾美斐生物医药科技有限公司 | 2024-06-14 | — | — | CN | claimed |