Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615946 | 0.89 | GBA1 (0.48) | GBA1PDPK1JAK2JAK3FADS1 | |
| SCHEMBL1615945 | 0.89 | GBA1 (0.48) | GBA1PDPK1JAK2JAK3FADS1 | |
| SCHEMBL1615788 | 0.86 | GBA1 (0.44) | GBA1PDPK1JAK2JAK3FADS1 | |
| SCHEMBL2245619 | 0.81 | GBA1 (0.47) | GBA1PDPK1FADS1PARP1HDAC6 | |
| SCHEMBL3844986 | 0.80 | PDPK1 (0.47) | GBA1PDPK1JAK2JAK3FADS1 | |
| SCHEMBL1616344 | 0.79 | GBA1 (0.46) | GBA1PDPK1JAK2JAK3FADS1 | |
| SCHEMBL1616343 | 0.79 | GBA1 (0.46) | GBA1PDPK1JAK2JAK3FADS1 | |
| SCHEMBL1616249 | 0.78 | GBA1 (0.50) | GBA1PDPK1FADS1PARP1HDAC6 | |
| SCHEMBL1616241 | 0.78 | GBA1 (0.50) | GBA1PDPK1FADS1PARP1HDAC6 | |
| SCHEMBL1616604 | 0.76 | GBA1 (0.43) | GBA1PDPK1FADS1PARP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099763-B1 | 2-AMINOQUINOLINES AS 5-HT(5A) RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |