Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926101 | 1.00 | HRH3 (0.48) | HRH3KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL2923294 | 0.82 | HRH3 (0.54) | HRH3KMT2A | |
| SCHEMBL2923295 | 0.82 | HRH3 (0.54) | HRH3KMT2A | |
| SCHEMBL2924472 | 0.80 | HRH3 (0.61) | HRH3 | |
| SCHEMBL2924469 | 0.80 | HRH3 (0.61) | HRH3 | |
| SCHEMBL2924527 | 0.79 | HRH3 (0.52) | HRH3KMT2AKDM4EMAPT | |
| SCHEMBL2924525 | 0.79 | HRH3 (0.52) | HRH3KMT2AKDM4EMAPT | |
| SCHEMBL2924865 | 0.79 | HRH3 (0.51) | HRH3ALDH1A1USP2HTTATM | |
| SCHEMBL2924869 | 0.79 | HRH3 (0.51) | HRH3ALDH1A1USP2HTTATM | |
| SCHEMBL2927433 | 0.71 | HRH3 (0.53) | HRH3KMT2AALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158189-B1 | CYCLOHEXYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |