Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.63 |
| ▸ | IKZF3 | Q9UKT9 | 11/20 | 0.63 |
| ▸ | TNF | P01375 | 6/20 | 0.59 |
| ▸ | IL1B | P01584 | 4/20 | 0.59 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30122062 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL31727416 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL29262028 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL29262073 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL24744806 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL31090548 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL24745307 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL29262124 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL31727937 | 1.00 | CRBN (0.63) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL19503643 | 0.89 | CRBN (0.66) | CRBNIKZF3TNFIL1BIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |