Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30121849 | 1.00 | KDM4E (0.42) | KDM4EGLAALDH1A1GAAKAT2B | |
| SCHEMBL24746810 | 0.94 | KDM4E (0.42) | KDM4EGLAALDH1A1GAAKAT2B | |
| SCHEMBL30121924 | 0.94 | KDM4E (0.42) | KDM4EGLAALDH1A1GAAKAT2B | |
| SCHEMBL28855763 | 0.84 | KAT2B (0.58) | KDM4EALDH1A1KAT2BKMT2AMEN1 | |
| SCHEMBL24744934 | 0.83 | KDM4E (0.45) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL28855675 | 0.82 | KAT2B (0.60) | KDM4EALDH1A1KAT2BKMT2AMEN1 | |
| SCHEMBL20810699 | 0.78 | KDM4E (0.46) | KDM4EGLAALDH1A1GAAKAT2B | |
| SCHEMBL30051772 | 0.78 | KDM4E (0.46) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL28855375 | 0.78 | KAT2B (0.58) | ALDH1A1KAT2BKMT2AMEN1MAPK1 | |
| SCHEMBL28855433 | 0.78 | KAT2B (0.55) | ALDH1A1KAT2BKMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |